# PART 1
# Why do i need BRCARE test?
- The most common female cancer in Korea
- Rapidly increased
- 1st in women cancer
- The incidence is decreasing in western countries
- People with a BRCA mutation shows that their children, siblings, and parents have a 50% chance of possessing the same autosomal dominant mutation.
# Hereditary Breast and Ovarian Cancer syndrome (HBOC)
- BRCA1 and BRCA2 mutations are known to put women at high risk.
- Hereditary Breast cancer accounts for 5-10% of all female breast cancer and this is caused by inherited mutations in BRCA 1 and BRCA 2.
- Patients with a BRCA mutation have up to an 80% risk of developing breast cancer and up to 50% risk of developing ovarian cancer in their lifetime.
- Primary breast cancer in the one breast has up to a 60% risk of developing breast cancer in the opposite breast as well.
- Patients with a BRCA2 mutation have up to a 6% risk of developing male breast cancer.
# What is the BRCA gene(Breast Cancer Gene)
- BRCA genes: human genes that produce tumor suppressor proteins. These proteins help repair damaged DNA
- BRCA1->located on chromosome 17
- BRCA2 ->located on chromosome 13
- Known genes causing inherited breast cancer
- People with BRCA1, BRCA2 mutations show that their children have a 50% chance of possessing the same autosomal dominant mutation.
# The importance of RARE genes in hereditary breast/ovarian cancer
*If you do not have a family history, the risk of developing breast cancer is up to 33% in 70 years of age. If you do, the risk is up to 58% in 50 years of age.
# PART 2
# What is the BRACARE® test?
- BRCARE® tests for BRCA1/2 genes using parallel sequencing for accuracy that compares between bioinformatics analysis and pathogenicity mutation.
- BRCARE® Plus tests rare genes mutation in TP53, PTEN, CDH1, and PALB2 for providing with precision analysis.
- 4 weeks to get result
- High detection rate(99.9%)
- Easily recognized report
- High- quality reference data
- Available with blood/saliva sample